Research report 2016 - Max Planck Institute for Experimental Medicine
The role of Kv10.1 potassium channel in cancer
Authors
Stühmer, Walter; Pardo, Luis A.
Departments
Molekulare Biologie Neuronaler Signale, Emeritusgruppe Arbeitsgruppe Onko-Physiologie
Summary
Ion channels are membrane proteins that regulate cellular processes by transmitting signals across membranes. Thus it is not surprising that they are also involved in cancer. In this respect, Kv10.1 is the most intensively studied potassium channel. It is overexpressed in over 70% of all cancer forms, and its expression level is up- and down-regulated during the cell cycle. This genetic regulation happens at the centre of signalling cascades involved in cancer and cell division regulation. Consequently, Kv10.1 represents a novel target for cancer treatment.