Developmental diversification of interneurons

The mammalian brain consists of hundreds of cell populations that all carry the same genetic information in the cell nucleus. How do neurons become specified as one differentiated subtype versus another? The ganglionic eminences (GE) are embryonic brain structures that produce many GABAergic cell types which disperse widely throughout the brain. We use single-cell RNA sequencing to profile the transcriptomes of developing neurons, in combination with genetic fate mapping techniques. Our findings shed new light on the molecular diversification of precursor cells.