Scientific Publications

Castro, C. F. G.; Nardiello, C.; Hadzic, S.; Kojonazarov, B.; Kraut, S.; Gierhardt, M.; Schaeffer, J.; Bednorz , M.; Quanz, K.; Heger, J. et al.; Korfei, M.; Wilhelm, J.; Hecker, M.; Bartkuhn, M.; Arnhold , S.; Guenther, A.; Seeger, Werner (Lung Development and Remodeling, Max Planck Institute for Heart and Lung Research, Max Planck Society), W.; Schulz, R.; Weissmann, N.; Sommer, N.; Pak, O.: The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung. AGING AND DISEASE (2024)

Hernandez-Olmos, V.; Heering, J.; Marinescu, B.; Schermeng, T.; Ivanov, V. V.; Moroz, Y. S.; Nevermann, S.; Mathes, M.; Ehrler, J. H. M.; Alnouri, M. W. et al.; Wolf, M.; Haydo, A. S.; Schmachtel, T.; Zaliani, A.; Ho''fner, G.; Kaiser, A.; Schubert-Zsilavecz, M.; Beck-Sickinger, A. G.; Offermanns, S.; Gribbon, P.; Rieger, M. A.; Merk, D.; Sisignano, M.; Steinhilber, D.; Proschak, E.: Development of a Potent and Selective G2A (GPR132) Agonist. JOURNAL OF MEDICINAL CHEMISTRY (2024)

Kumari, P.; Tarighi, S.; Fuchshuber, E.; Li, L.; Fernandez-Duran, I.; Wang, M.; Ayoson, J.; Castello-Garcia, J. M.; Gamez-Garcia, A.; Espinosa-Alcantud, M. et al.; Sreenivasan, K.; Guenther, S.; Olivella, M.; Savai, R.; Yue, S.; Vaquero, A.; Braun, T.; Ianni, A.: SIRT7 promotes lung cancer progression by destabilizing the tumor suppressor ARF. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (25), e2409269121 (2024)

Budczies, J.; Romanovsky, E.; Kirchner, M.; Neumann, O.; Blasi, M.; Schnorbach, J.; Shah, R.; Bozorgmehr, F.; Savai, R.; Stiewe, T. et al.; Peters, S.; Schirmacher, P.; Thomas, M.; Kazdal, D.; Christopoulos, P.; Stenzinger, A.: KRAS and TP53 co-mutation predicts benefit of immune checkpoint blockade in lung adenocarcinoma. BRITISH JOURNAL OF CANCER (2024)

Brichkina, A.; Ems, M.; Suezov, R.; Singh, R.; Lutz, V.; Picard, F. S. R.; Nist, A.; Stiewe, T.; Graumann, J.; Daude, M. et al.; Diederich, W. E.; Finkernagel, F.; Chung, H.-R.; Bartsch, D. K.; Roth, K.; Keber, C.; Denkert, C.; Huber, M.; Gress, T. M.; Lauth, M.: DYRK1B blockade promotes tumoricidal macrophage activity in pancreatic cancer. GUT (2024)

Zhu, Y.; Ackers-Johnson, M.; Shanmugam, M. K.; Pakkiri, L. S.; Drum, C. L.; Chen, Y.; Kim, J.; Paltzer, W. G.; Mahmoud, A. I.; Tan, W. L. W. et al.; Lee, M. C. J.; Jiang, J.; Luu, D. A. T.; Ng, S. L.; Li, P. Y. Q.; Wang, A.; Qi, R.; Ong, G. J. X.; Ng, T. Y.; Haigh, J. J.; Tiang, Z.; Richards, A. M.; Foo, R. S. Y.: Asparagine Synthetase Marks a Distinct Dependency Threshold for Cardiomyocyte Dedifferentiation. CIRCULATION 149 (23), pp. 1833 - 1851 (2024)

Gauvrit, S.; Zhao, S.; Rothbauer, U.; Stainier, D. Y. R.: A β-catenin chromobody-based probe highlights endothelial maturation during vascular morphogenesis in vivo. DEVELOPMENT 151 (11), dev202122 (2024)

Nawn , D.; Hassan, S. S.; Redwan, E. M.; Bhattacharya, T.; Basu, P.; Lundstrom, K.; Uversky, V. N.: Unveiling the genetic tapestry: Rare disease genomics of spinal muscular atrophy and phenylketonuria proteins. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 269, 131960 (2024)

Schlueter, B. C.; Quanz, K.; Baldauf, J.; Petrovic, A.; Ruppert, C.; Guenther, A.; Gall, H.; Tello, K.; Grimminger, F.; Ghofrani, H. -. et al.; Weissmann, N.; Seeger, W.; Schermuly, R. T.; Weiss, A.: The diverging roles of insulin-like growth factor binding proteins in pulmonary arterial hypertension. VASCULAR PHARMACOLOGY 155, 107379 (2024)

Brunnberg, J.; Barends, M.; Fruehschulz, S.; Winter, C.; Battin, C.; de Wet, B.; Cole, D. K.; Steinberger, P.; Tampe, R.: Dual role of the peptide- loading complex as proofreader and limiter of MHC- I presentation. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 121 (22), e2321600121 (2024)

Ribeiro da Silva, A.; Gunawan, F.; Boezio, G. L. M.; Faure , E.; Theron , A.; Avierinos , J.-F.; Lim, S.; Shivam, G. J.; Ramadass, R.; Guenther, S. et al.; Looso, M.; Zaffran, S.; Juan, T.; Stainier, D. Y. R.: egr3 is a mechanosensitive transcription factor gene required for cardiac valve morphogenesis. SCIENCE ADVANCES 10 (20), eadl0633 (2024)

Tamiato, A.; Tombor, L. S.; Fischer, A.; Muhly-Reinholz, M.; Vanicek, L. R.; Togru, B. N.; Neitz, J.; Glaser, S. F.; Merten, M.; Morales, D. R. et al.; Kwon, J.; Klatt, S.; Schumacher, B.; Guenther, S.; Abplanalp, W. T.; John, D.; Fleming, I.; Wettschureck, N.; Dimmeler, S.; Luxaen, G.: Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis. CIRCULATION RESEARCH 134 (10), pp. 1240 - 1255 (2024)

Wang, T.; Shao, J.; Shamit, K.; Alnouri, M. W.; Carvalho, J.; Guenther, S.; Krasel , C.; Murphy, K. T.; Buenemann, M.; Offermanns, S. et al.; Wettschureck, N.: Orphan GPCR GPRC5C Facilitates Angiotensin II-Induced Smooth Muscle Contraction. CIRCULATION RESEARCH 134 (10), pp. 1259 - 1275 (2024)

Cardeira-da-Silva, J.; Wang, Q.; Sagvekar, P.; Mintcheva, J.; Latting, S.; Guenther, S.; Ramadass, R.; Yekelchyk, M.; Preussner, J.; Looso, M. et al.; Junker, J. P.; Stainier, D. Y. R.: Antigen presentation plays positive roles in the regenerative response to cardiac injury in zebrafish. NATURE COMMUNICATIONS 15 (1), 3637 (2024)

Martin, D.; Roedel, F.; Hehlgans, S.; Looso, M.; Ziegler, P. K.; Fleischmann, M.; Diefenhardt, M.; Fries, L.; Kalinauskaite, G.; Tinhofer, I. et al.; Zips, D.; Gani, C.; Roedel, C.; Fokas, E.: Inflammatory pathways confer resistance to chemoradiotherapy in anal squamous cell carcinoma. NPJ PRECISION ONCOLOGY 8 (1), 93 (2024)

Schultheis, H.; Bentsen, M.; Heger, V.; Looso, M.: Uncovering uncharacterized binding of transcription factors from ATAC-seq footprinting data. SCIENTIFIC REPORTS 14 (1), 9275 (2024)

Neuhaus, F.; Lieber, S.; Shinkevich, V.; Steitz, A. M.; Raifer, H.; Roth, K.; Finkernagel, F.; Worzfeld, T.; Burchert, A.; Keber, C. et al.; Nist, A.; Stiewe, T.; Reinartz, S.; Beutgen, V. M.; Graumann, J.; Pauck, K.; Garn, H.; Gaida, M.; Mueller, R.; Huber, M.: Reciprocal crosstalk between Th17 and mesothelial cells promotes metastasis-associated adhesion of ovarian cancer cells. CLINICAL AND TRANSLATIONAL MEDICINE 14 (4), e1604 (2024)

Schevenels, G.; Cabochette, P.; America, M.; Vandenborne, A.; De Grande, L.; Guenther, S.; He, L.; Dieu, M.; Christou, B.; Vermeersch, M. et al.; Germano, R. F. V.; Perez-Morga, D.; Renard, P.; Martin, M.; Vanlandewijck, M.; Betsholtz, C.; Vanhollebeke, B.: A brain-specific angiogenic mechanism enabled by tip cell specialization. NATURE 628 (8009) (2024)

Takahashi, H.; Eguchi, J.; Watanabe, M.; Nakayama, M.; Wada, J.: Reduced Immunogenicity of COVID-19 Vaccine in Obese Patients with Type 2 Diabetes: A Cross-Sectional Study. ACTA MEDICA OKAYAMA 78 (2), pp. 185 - 191 (2024)

Vega-Sendino, M.; Luettmann, F. F.; Olbrich, T.; Chen, Y.; Kuenne, C.; Stein, P.; Tillo, D.; Carey, G. I.; Zhong, J.; Savy, V. et al.; Radonova, L.; Lu, T.; Saykali, B.; Kim, K.-P.; Domingo, C. N.; Schueler, L.; Guenther, S.; Bentsen, M.; Bosnakovski, D.; Schoeler, H.; Kyba, M.; Maity, T. K.; Jenkins, L. M.; Looso, M.; Williams, C. J.; Kim, J.; Ruiz, S.: The homeobox transcription factor DUXBL controls exit from totipotency. NATURE GENETICS (56), pp. 697 - 709 (2024)