Targeted chemical control of protein interactions

The spatial proximity of proteins plays an central role in biological processes in cells. Protein modifications such as methylation bring biomolecules into proximity to one another, which regulates cellular processes. For the study of such mechanisms, chemical inducers of proximity (CIPs) have been developed. These chemical compounds allow targeted manipulation of the spatial organization of proteins in biological systems. At the MPI for Medical Research, a new CIP was developed using mandipropamid, which is characterized by its high efficiency and is ideally suited for in vivo use.