How do our cells stay fit: A structural analysis of the corona reveals the secrets of cell division

Billions of cells in our body constantly undergo cell division, a complex process that usually occurs error-free in healthy cells. Even minor errors can result in cell degeneration or resistance to chemotherapy. The kinetochore, a complex, multi-layered protein structure attached to the chromosome, monitors faithful cell division. We reconstituted the main components of its outermost layer, the corona, determined its structure, and unveiled its cellular function. Our findings significantly advance our understanding of cell division in healthy and malignant cells.