Research report 2023 - Max Planck Institute for Biology of Ageing
Malonyl-CoA links lipid metabolism to nutrient signalling by directly inhibiting mTORC1
Authors
Demetriades, Constantinos
Departments
Forschungsgruppe Steuerung des Zellwachstums im gesunden Zustand und bei altersbedingten Erkrankungen
Summary
Cells use various metabolic pathways to synthesize the building blocks for growth and proliferation. To ensure balanced growth, these biosynthetic processes must be tightly coordinated. In contrast, dysregulation of these cellular pathways is tightly linked to human diseases and ageing. Our work describes a molecular machinery that senses the cellular capacity to make lipids to then regulate other biosynthetic processes, like protein synthesis, accordingly.