Born 1964 in Berlin. Studies in medicine in Berlin and London; doctorate from the Free University of Berlin (1991). Postdoc at the California Institute of Technology (1994-1997). Heisenberg fellowship holder, Free University of Berlin (1998). Professor and Director at the Pharmacological Institute, University of Heidelberg (2000-2009). Director and Scientific Member at the Max Planck Institute for Heart and Lung Research (since 2008) and Professor of Pharmacology, Goethe University, Frankfurt (since 2009).