Scientific Publications

Licheva, M.; Babic, R.; Pflaum, J.; Mancilla, H.; Wilfling, F.; Kraft, C.: To degrade or not to degrade: how phase separation modulates selective autophagy. Autophagy (2025)

Zimmann, F.; McNicoll, F.; Thakur, P. K.; Blažíková, M.; Kubovčiak, J.; Hernández Cañás, M. C.; Nováková, Z.; Bařinka, C.; Kolář, M.; Staněk, D. et al.; Müller-McNicoll, M.; Cvačková, Z.: Retinitis pigmentosa-linked mutations impair the snRNA unwinding activity of SNRNP200 and reduce pre-mRNA binding of PRPF8. Cellular and Molecular Life Sciences 82, 103 (2025)

Klumpe, S.; Senti, K. A.; Beck, F.; Sachweh, J.; Hampoelz, B.; Ronchi, P.; Oorschot, V.; Brandstetter, M.; Yeroslaviz, A.; Briggs, J. A. G. et al.; Brennecke, J.; Beck, M.; Plitzko, J. M.: In-cell structure and snapshots of copia retrotransposons in intact tissue by cryoelectron tomography. Cell 188 (2025)

Cortés Rodríguez, F. J.; Frattini, G.; Phloi-Montri, S.; Pinto Meireles, F. T.; Terrien, D. A.; Cruz-León, S.; Dal Peraro, M.; Schier, E.; Lindorff-Larsen, K.; Limpanuparb, T. et al.; Moreno, D. M.; Abriata, L. A.: MolecularWebXR: Multiuser discussions in chemistry and biology through immersive and inclusive augmented and virtual reality. Journal of Molecular Graphics and Modelling 135, 108932 (2025)

Poveda Cuevas, S. A.; Lohachova, K.; Markusic, B.; Dikic, I.; Hummer, G.; Bhaskara, R.: Janus-like behavior of intrinsically disordered regions in reticulophagy. Autophagy 21 (3), pp. 681 - 683 (2025)

Smarduch, S.; Moreno-Velasquez, S. D.; Ilic, D.; Dadsena, S.; Morant, R.; Ciprinidis, A.; Pereira, G.; Binder, M.; García-Sáez, A. J.; Acebrón, S. P.: A novel biosensor for the spatiotemporal analysis of STING activation during innate immune responses to dsDNA. The EMBO Journal (2025)

Bailey, H. J.; Eisert, J.; Kazi, R.; Gerhartz, J.; Pieńkowska, D. E.; Dressel, I.; Vollrath, J.; Kondratov, I.; Matviyuk, T.; Tolmachova, N. et al.; Shah, V. J.; Giuliani, G.; Mosler, T.; Geiger, T. M.; Esteves, A. M.; Santos, S. P.; Sousa, R. L.; Bandeiras, T. M.; Leibrock, E.-M.; Bauer, U.; Leuthner, B.; Langer, J. D.; Wegener, A. A.; Nowak, R. P.; Sorrell, F. J.; Đikić, I.: An engineered cereblon optimized for high throughput screening and molecular glue discovery. Cell Chemical Biology 32 (2), pp. 363 - 376.e10 (2025)

Kreysing, J. P.; Heidari, M.; Zila, V.; Cruz-León, S.; Obarska-Kosinska, A.; Laketa, V.; Rohleder, L.; Welsch, S.; Köfinger, J.; Turoňová, B. et al.; Hummer, G.; Kräusslich, H.-G.; Beck, M.: Passage of the HIV capsid cracks the nuclear pore. Cell 188 (4), pp. 930 - 943.e21 (2025)

Kutzner, C.; Miletić, V.; Palacio Rodríguez, K.; Rampp, M.; Hummer, G.; de Groot, B. L.; Grubmüller, H.: Scaling of the GROMACS Molecular Dynamics Code to 65k CPU Cores on an HPC Cluster. Journal of Computational Chemistry 46 (5), e70059 (2025)

Lee, Y.; Jin, C.; Ohgaki, R.; Xu, M.; Ogasawara, S.; Warshamanage, R.; Yamashita, K.; Murshudov, G.; Nureki, O.; Murata, T. et al.; Kanai, Y.: Structural basis of anticancer drug recognition and amino acid transport by LAT1. Nature Communications 16, 1635 (2025)

Cook, A. S. I.; Chen, M.; Nguyen, T. N.; Cabezudo, A. C.; Khuu, G.; Rao, S.; Garcia, S. N.; Yang, M.; Iavarone, A. T.; Ren, X. et al.; Lazarou, M.; Hummer, G.; Hurley, J. H.: Structural pathway for PI3-kinase regulation by VPS15 in autophagy. Science (2025)

Hoffmann, P. C.; Kim, H.; Obarska-Kosinska, A.; Kreysing, J. P.; Andino-Frydman, E.; Cruz-León, S.; Margiotta, E.; Cernikova, L.; Kosinski, J.; Turoňová, B. et al.; Hummer, G.; Beck, M.: Nuclear pore permeability and fluid flow are modulated by its dilation state. Molecular Cell 85 (3), pp. 537 - 554.e11 (2025)

Cutts, E. E.; Tetiker, D.; Kim, E.; Aragon, L.: Molecular mechanism of condensin I activation by KIF4A. The EMBO Journal 44 (3), pp. 682 - 704 (2025)

Licheva, M.; Pflaum, J.; Babic, R.; Mancilla, H.; Elsässer, J.; Boyle, E.; Hollenstein, D. M.; Jimenez-Niebla, J.; Pleyer, J.; Heinrich, M. et al.; Wieland, F.-G.; Brenneisen, J.; Eickhorst, C.; Brenner, J.; Jiang, S.; Hartl, M.; Welsch, S.; Hunte, C.; Timmer, J.; Wilfling, F.; Kraft, C.: Phase separation of initiation hubs on cargo is a trigger switch for selective autophagy. Nature Cell Biology 27 (2), pp. 283 - 297 (2025)

Rutkauskas, M.; Kim, E.: In vitro dynamics of DNA loop extrusion by structural maintenance of chromosomes complexes. Current Opinion in Genetics & Development 90, 102284 (2025)

Yin, M. D.; Lemaire, O. N.; Rosas Jiménez, J. G.; Belhamri, M.; Shevchenko, A.; Hummer, G.; Wagner, T.; Murphy, B. J.: Conformational dynamics of a multienzyme complex in anaerobic carbon fixation. Science 387 (6733), pp. 498 - 504 (2025)

Pedrera, L.; Prieto Clemente, L.; Dahlhaus, A.; Lotfipour Nasudivar, S.; Tishina, S.; Olmo González, D.; Stroh, J.; Yapici, F. I.; Singh, R. P.; Grotehans, N. et al.; Langer, T.; García-Sáez, A. J.; von Karstedt, S.: Ferroptosis triggers mitochondrial fragmentation via Drp1 activation. Cell Death and Disease 16, 40 (2025)

Introini, B.; Hahn, A.; Kühlbrandt, W.: Cryo-EM structure of the NDH-PSI-LHCI supercomplex from Spinacia oleracea. Nature Structural & Molecular Biology (2025)

Xing, H.; Rosenkranz, R. R. E.; Rodriguez-Aliaga, P.; Lee, T.-T.; Majtner, T.; Böhm, S.; Turoňová, B.; Frydman, J.; Beck, M.: In situ analysis reveals the TRiC duty cycle and PDCD5 as an open-state cofactor. Nature 637 (8047), pp. 983 - 990 (2025)

Kraus, F.; He, Y.; Swarup, S.; Overmyer, K. A.; Jiang, Y.; Brenner, J.; Capitanio, C.; Bieber, A.; Jen, A.; Nightingale, N. M. et al.; Anderson, B. J.; Lee, C.; Paulo, J. A.; Smith, I. R.; Plitzko, J. M.; Gygi, S. P.; Schulman, B. A.; Wilfling, F.; Coon, J. J.; Harper, J. W.: Global cellular proteo-lipidomic profiling of diverse lysosomal storage disease mutants using nMOST. Science Advances 11 (4), eadu5787 (2025)